Dr. 杰森山木
- 教育:
- 加州 State University, Dominguez Hills, Bachelor of Science
University of Southern 加州, Doctor of Pharmacy
南加州大学，博士.D.
传记
In addition to the degrees listed in the education section Education above, Dr. Yamaki holds the following credential: RPh. Dr. Yamaki completed his Bachelor’s degree in Microbiology from 加州 State University Dominguez Hills in May 2005. 随后, he completed his PharmD and PhD degrees at the University of Southern 加州 药学院 in 2009 and 2013, 分别. 在2014年5月加入CUSP之前，博士. Yamaki was a Post-Doc 研究 Associate at the University of Southern 加州, 药学院 as well as a lecturer in the 传染病 module. 在南加州大学期间. Yamaki was awarded a highly competitive Clinical & Translational Science Institute pilot grant.
Dr. Yamaki’s area of research interests is in 传染病. His research combines both molecular and pharmacological approaches to address the therapeutic challenges of treating multidrug resistant and highly virulent bacteria. 到目前为止，. Yamaki’s research has focused on the epidemiology of Methicillin-Resistant 金黄色葡萄球菌 (MRSA), 病人的结果 and host response in various types of infections caused by MRSA, and the effects of inadequate antibiotic dosing on virulence and disease severity. Thus far his research methods have encompassed in-vitro cellular and in-vivo murine models of infection, epidemiologic and retrospective patient outcome studies, 以及前瞻性临床研究.
Dr. Yamaki’s future studies will continue to explore virulence and 电阻 in MRSA, and as there are an increasing number of different drug resistant and virulent bacteria causing serious infections, exploration of novel therapeutic agents against various multidrug resistant organisms is planned.
研究兴趣
Dr. Yamaki’s research focuses on Methicillin-Resistant 金黄色葡萄球菌 (MRSA)毒性, 电阻, 分子流行病学, 病人的结果, 以及宿主对感染的反应. His research has explored the contribution of highly virulent 社区 Associated-MRSA strains in patient infections, 这些菌株产生外毒素, and modulatory effects by sub-inhibitory antibiotics on exotoxin production. Exotoxin contribution to disease and modulatory effects of antibiotics are tested in both in-vitro cell culture and murine models of infection. Aside from designing and performing laboratory experiments he has been involved in designing and conducting a number of clinical studies. 而博士. Yamaki的研究重点是MRSA, investigations into other highly drug resistant and virulent bacteria are planned in the near future.
Recent Creative, Scholarly Work and Publications
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Yamaki J, Chawla S, Tong S, Lozada KA, Yang S. Iron Effects on Clostridioides difficile Toxin Production and Antimicrobial Susceptibilities. 抗生素. 2022; 11(5):537
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William Truong, Richard Beuttler, Philip Robinson, 杰森山木. Impact of Non-Restrictive Antimicrobial Stewardship Interventions on Levofloxacin Use. 传染病公开论坛8/2022
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Ross C, Syed B, Pak J, Jhanji V, Yamaki J, Sharma A. Stability Evaluation of Extemporaneously Compounded Vancomycin Ophthalmic Drops: Effect of Solvents and Storage Conditions. 制药学. 2021; 13(2):289.
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张伟霆, 艾力达希, 迈克尔·A·波拉里斯, 李阮, 杰森山木, The antibiogram: key considerations for its development and utilization, JAC-Antimicrobial阻力, 卷3, 问题2, 2021年6月
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杰森山木 & 李阮 (2020) A brief evaluation of vancomycin loading doses and nephrotoxicity in the elderly population, 传染病, 52:10, 751-754, DOI: 10.1080/23744235.2020.1784998
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山木J.， Peled, H.马修斯，S. 等. Seroprevalence of Novel Coronavirus SARS-CoV-2 at a 社区 Hospital 紧急 Department and Outpatient Laboratory in Northern Orange County, 加州. J. Racial and Ethnic Health Disparities (2020).
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张伟霆, 徐志强, 杰森山木, Oral Antibiotic Prescribing in Healthcare-associated Pneumonia Patients at Hospital Discharge, 临床传染病, , ciz340, http://doi.org/10.1093/cid/ciz340
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Truong WR, 赢得了KJ, Yamaki J;"Antibiotic selection and isolate susceptibility profile in patients who failed ciprofloxacin or TMP-SMX for pyelonephritis", 美国急诊医学杂志, 2019
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Truong WR and Yamaki J; "Distinctive Nitrofurantoin Formulations for the Treatment and Prophylaxis of Urinary Tract Infections", J Urol. 2019 Aug 20:101097JU0000000000000502.
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Riahifard N.莫扎法里，S.Aldakhil, T.努涅斯，F.阿尔沙玛里，Q.美国阿尔沙马里.蒂瓦里，R. K. (2018). 设计, 合成, and Evaluation of Amphiphilic Cyclic and Linear Peptides Composed of Hydrophobic and Positively-Charged Amino Acids as Antibacterial Agents. 分子 (Basel, Switzerland), 23(10), 2722. doi: 10.3390 / molecules23102722
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Riahifard N, Tavakoli K, Yamaki J, Parang K, Tiwari R. 合成 and Evaluation of Antimicrobial Activity of [R4W4K]-Levofloxacin and [R4W4K]-Levofloxacin-Q Conjugates. 分子. 2017; 22(6):957.