Dr. Jennifer Totonchy
- Education:
- Northwestern University, Bachelor of Arts
Oregon Health Science University, Ph.D.
Biography
Dr. Jennifer Totonchy joined CUSP on November 1, 2016年担任免疫学和免疫治疗学助理教授. Dr. Totonchy completed her PhD in Molecular Microbiology and Immunology (working on subversion of host cytokine signaling by Human Cytomegalovirus and its contribution to solid organ allograft rejection) at Oregon Health and Science University in 2010 and did postdoctoral fellowships (working on the pathogenesis of Kaposi Sarcoma Herpesvirus in endothelial cells and B lymphocytes) at Oregon Health and Science University from 2010 to 2013 and Weill Cornell Medical College in New York City from 2013 to 2016. In 2014, 她被国家牙科和颅面研究所授予K99/R00独立途径奖，以继续她在人类扁桃体卡波西肉瘤疱疹病毒感染的基本病毒学方面的工作. Dr. Totonchy撰写了13篇同行评审的出版物和10篇会议摘要.
Research Interests
Dr. Totonchy的研究重点是卡波西肉瘤疱疹病毒(KSHV)，特别是确定KSHV如何通过感染口腔淋巴组织中的细胞进入人类宿主. 她的研究利用来自人类扁桃体组织的多种原代细胞类型来确定参与早期感染事件的病毒和细胞基因. 她最近对KSHV感染B淋巴细胞的研究揭示了KSHV操纵B细胞生理的新机制. In particular, Dr. Totonchy感兴趣的是描述包装在病毒颗粒中的功能性病毒蛋白的作用, 在B淋巴细胞感染的早期事件中被称为被膜蛋白. B淋巴细胞中KSHV被膜蛋白的研究对KSHV相关人类疾病的预防和治疗具有重要意义，但也是一个有趣的系统，可用于揭示B淋巴细胞特异性生理学，以便开发针对其他疾病的B细胞靶向免疫治疗范例.
Recent Creative, Scholarly Work and Publications
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Alwadei N, Rashid M, Chandrashekar DV, Rahighi S, Totonchy J, Sharma A, Mehvar R. 过表达CYP2E1的HepG2细胞的产生及表征研究CYP2E1在肝脏缺氧-再氧化损伤中的作用. Int J Mol Sci. 2023 May 1;24(9):8121. doi: 10.3390/ijms24098121. PMID: 37175827
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Cesarman E, Totonchy J. Editorial overview: Viruses and Cancer. Curr Opin Virol. 2023 Oct;62:101364. doi: 10.1016/j.coviro.2023.101364. Epub 2023 Sep 4. PMID: 37672873
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Alomari N, Totonchy J. IL-21信号通过增加浆细胞的分化和靶向性，促进KSHV感染在人扁桃体淋巴细胞中的建立. Front Immunol. 2022 Dec 7;13:1010274. doi: 10.3389/fimmu.2022.1010274. PMID: 36569889; PMCID: PMC9769966.
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Alomari N, Totonchy J. 宿主水平易感性和IRF1表达影响IFN-的能力? to Inhibit KSHV Infection in B Lymphocytes. Viruses. 2022 Oct 19;14(10):2295. doi: 10.3390/v14102295. PMID: 36298850; PMCID: PMC9607942.
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namyw, Kong D, Wang D, Orfali R, Sherpa RT, Totonchy J, Nauli SM，张敏. 磷酸化对SK通道亚型的差异调节. Cell Calcium. 2021 Mar;94:102346. doi: 10.1016/j.ceca.2020.102346. Epub 2021 Jan 6. PMID: 33422768; PMCID: PMC8415101.
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杨建军，杨建军，李建军，李建军. Suppression of DC-SIGN and gH Reveals Complex, KSHV进入原发性B淋巴细胞的亚群特异性机制. Viruses. 2021 Jul 31;13(8):1512. doi: 10.3390/v13081512. PMID: 34452377; PMCID: PMC8402705.
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李勇，Duche A, Sayer MR, Roosan D, Khalafalla FG, Ostrom RS, Totonchy J, Roosan MR. SARS-CoV-2早期感染特征确定了潜在的关键感染机制和药物靶点. BMC Genomics. 2021 Feb 18;22(1):125. doi: 10.1186/s12864-021-07433-4. PMID: 33602138; PMCID: PMC7889713.
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Qadri M, Jay GD，张立新，Schmidt TA, Totonchy J, Elsaid KA. 蛋白聚糖-4是滑膜巨噬细胞极化和炎性巨噬细胞关节浸润的重要调节因子. Arthritis Res Ther. 2021 Sep 14;23(1):241. doi: 10.1186/s13075-021-02621-9. Erratum in: Arthritis Res Ther. 2021 Oct 29;23(1):276. PMID: 34521469; PMCID: PMC8439011.
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El-Sayed NS, Jureka AS, Edwards MR, Lohan S, Williams CG, Keiser PT, Davey RA, Totonchy J, Tiwari RK, Basler CF, Parang K. 瑞德西韦脂肪酰基偶联物的合成及其对严重急性呼吸综合征冠状病毒2型和埃博拉病毒的抗病毒活性. Eur J Med Chem. 2021 Dec 15;226:113862. doi: 10.1016/j.ejmech.2021.113862. Epub 2021 Sep 21. PMID: 34583312; PMCID: PMC8454092.
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刘建军，李建军，李建军，李建军，李建军，李建军. 移植物抗宿主病相关结膜纤维化的局部肾素-血管紧张素系统激活和肌成纤维细胞形成. Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):10. doi: 10.1167/iovs.62.13.10. PMID: 34643664; PMCID: PMC8525838.
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Muniraju M, Mutsvunguma LZ, Foley J, Escalante GM, Rodriguez E, Nabiee R, Totonchy J, Mulama DH, Nyagol J, Wussow F, Barasa AK, Brehm M, Ogembo JG. 卡波西肉瘤相关疱疹病毒糖蛋白H在上皮细胞感染中不可或缺, Endothelial, and Fibroblast Cell Types. J Virol. 2019 Aug 15;93(16). doi: 10.1128/JVI.00630-19. Print 2019 Aug 15. PubMed PMID: 31142670
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Mulama DH, Mutsvunguma LZ, Totonchy J, Ye P, Foley J, Escalante GM, Rodriguez E, Nabiee R, Muniraju M, Wussow F, Barasa AK, Ogembo JG. 一种多价卡波西肉瘤相关疱疹病毒样颗粒疫苗，能够在免疫兔中引发高滴度的中和抗体. Vaccine. 2019 Jul 9;37(30):4184-4194. doi: 10.1016/j.vaccine.2019.04.071. Epub 2019 Jun 11. PubMed PMID: 31201053.
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Broeckel R, Sarkar S, May NA, Totonchy J, Kreklywich CN, Smith P, Graves L, DeFilippis VR, Heise MT, Morrison TE, Moorman N, Streblow DN. Src家族激酶抑制剂阻断甲病毒亚基因组mrna的翻译. Antimicrob Agents Chemother. 2019 Apr;63(4). doi: 10.1128/AAC.02325-18. Print 2019 Apr. PubMed PMID: 30917980; PubMed Central PMCID: PMC6496153.
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刘建军，张建军，李建军，* * * * *. KSHV诱导成熟B淋巴细胞的免疫球蛋白重排. PLoS Pathog. 2018 Apr;14(4):e1006967. PubMed PMID: 29659614; PubMed Central PMCID: PMC5919685.
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Totonchy, J. 滤泡外活动:HIV感染的观点, germinal center-independent maturation pathways, and KSHV-mediated lymphoproliferation. Current Opinion in Virology. 2017, Aug 2;26:69-73.